Why yet another rsync wrapper for the Mac? Because I really felt there was't one that met my needs:

• Simple Finder-based source selection - just label everything important with the Violet label.
• Exclusion list support - if there's anything inside the important folder that you don't want to back up (say Microsoft User Data in you Documents), just mark it with a Gray label
• Added flexibility via Smart Searches - just save a search as “Macup” to really fine tune your selection criteria.
• Easy scheduling via iCal
• Using rsync is really fast, reliable, transparent and good for the soul :P
• Completely faceless interface
• Growl notifications

The app is currently Intel-only. Download here.